Artificial Saliva for Therapeutic Management of Xerostomia: A Narrative Review
Hajer Ayed Alhejoury, Lina Fouad Mogharbel, Mohammed Ahmed Al-Qadhi, Suzan Sulaiman Shamlan, Amal Fuad Alturki, Wafaa Mohammed Babatin, Renad Abdualrahman Mohammed Alaishan, Fawaz Pullishery
Abstract
In clinical practice, xerostomia or oral dryness is a chronic disease condition encountered by most dentists and dental hygienists, which often causes a negative impact on the oral health-related quality of life of the affected individual. Xerostomia is caused due to salivary gland dysfunction. It is related to reduced salivary secretion or the absence of saliva flow, more frequently, exhibits qualitative changes in saliva proteins and immunoglobulin concentrations that arise due to salivary gland dysfunction. This condition causes discomfort and interferes with normal oral activities, and affected individuals are at high caries risk. There are several options for treatment and symptom management: salivary stimulants, topical agents, saliva substitutes, and systemic sialogogues. This review explores the current status of therapeutic management of patients affected by xerostomia and hyposalivation using artificial saliva.