Engineered myoglobin as a catalyst for atom transfer radical cyclisation
Andriy Lubskyy, Chao Guo, Robert J. Chadwick, Alke Petri‐Fink, Nico Bruns, Michela M. Pellizzoni
Abstract
cyclisation of halogenated unsaturated compounds for the synthesis of γ-lactams. This new-to-nature activity was achieved not only with purified protein but also in crude cell lysate and in whole cells.
Topics & Concepts
MyoglobinChemistryHistidineCatalysisIntramolecular forceMutagenesisMetalloproteinLysisActive siteSerineCombinatorial chemistryStereochemistryAmino acidOrganic chemistryBiochemistryMetalEnzymeMutationGeneRadical Photochemical ReactionsClick Chemistry and ApplicationsChemical Synthesis and Analysis