Design, synthesis, and biological evaluation of pyrido[3,2-d]pyrimidine derivatives as novel ATR inhibitors
Yunxin Duan, Lili Zhuang, Yerong Xu, Haodong Cheng, Jiawei Xia, Tao Lu, Yadong Chen
Topics & Concepts
ChemistryPyrimidineLead compoundBiochemistryPyrimidine analogueStructure–activity relationshipKinaseDrugBiological activityPotencyDNA damageCombinatorial chemistryPharmacologyDNAIn vitroBiologyDNA Repair MechanismsCell death mechanisms and regulationCancer therapeutics and mechanisms