RORγt phosphorylation protects against T cell-mediated inflammation
Shengyun Ma, Shefali A. Patel, Yohei Abe, Nicholas Chen, Parth Patel, Benjamin S. Cho, Nazia Abbasi, Su-Ling Zeng, Bernd Schnabl, John T. Chang, Wendy Huang
Abstract
circuit protects against T cell-mediated inflammation and provides potential therapeutic targets to combat autoimmune diseases.
Topics & Concepts
RAR-related orphan receptor gammaExperimental autoimmune encephalomyelitisInflammationCell biologyT cellOrphan receptorPhosphorylationBiologySignal transductionImmune systemMAPK/ERK pathwayKinaseTranscription factorImmunologyCancer researchFOXP3BiochemistryGeneCytokine Signaling Pathways and InteractionsPsoriasis: Treatment and PathogenesisProtein Tyrosine Phosphatases