Catalytic charge transfer complex enabled difluoromethylation of enamides with difluoromethyltriphenylphosphonium bromide
Ping Li, Qiang Liu, Dequn Sun, Xiang‐Yu Chen
Abstract
A catalytic charge transfer complex strategy that enabled difluoromethylation and ethoxycarbonylmonofluoromethylation of enamides with phosphonium bromine salts has been reported. This strategy also provides a convenient approach for the synthesis of functionalized oxindoles and 1,1-diphenylethylenes with easily available phosphonium bromine salts and a catalytic amount of iodine anion.
Topics & Concepts
PhosphoniumChemistryBromineBromideCatalysisCombinatorial chemistryPhosphonium saltIodineOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions