Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model
Xuan Li, Yuting Ren, Guowen Huang, Ruofan Zhang, Yanan Zhang, Weiyun Zhu, Kaifan Yu
Abstract
SUCNR1 in the intestine, and the pro-inflammatory cytokines induced by succinate blocked the activation of FXR and its target genes and disturbed bile acid enterohepatic circulation.
Topics & Concepts
Enterohepatic circulationMetabolismHost (biology)Bile acidChemistryBiochemistryBiologyEcologyDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsClinical Nutrition and Gastroenterology