Regulatory Effects of Histone Deacetylase Inhibitors on Myeloid-Derived Suppressor Cells
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Abstract
Histone deacetylase inhibitors (HDACIs) are antitumor drugs that are being developed for use in clinical settings. HDACIs enhance histone or nonhistone acetylation and promote gene transcription via epigenetic regulation. Importantly, these drugs have cytotoxic or cytostatic properties and can directly inhibit tumor cells. However, how HDACIs regulate immunocytes in the tumor microenvironment, such as myeloid-derived suppressor cells (MDSCs), has yet to be elucidated. In this review, we summarize the effects of different HDACIs on the immunosuppressive function and expansion of MDSCs based on the findings of relevant studies.
Topics & Concepts
AcetylationHistone deacetylaseEpigeneticsCancer researchHistoneMyeloid-derived Suppressor CellHistone deacetylase 2SuppressorHDAC1VorinostatHDAC10Histone deacetylase inhibitorChemistryBiologyGeneBiochemistryHistone Deacetylase Inhibitors ResearchImmune cells in cancerMacrophage Migration Inhibitory Factor