Ghrelin deficiency sex-dependently affects food intake, locomotor activity, and adipose and hepatic gene expression in a binge-eating mouse model
Karina Prins, Martin Huisman, Anke McLuskey, Rosinda Mies, Bas Karels, Patric J. D. Delhanty, Jenny A. Visser
Abstract
Ghrelin, a peptide hormone secreted from the gut, is involved in hunger and reward signaling, which are altered in binge-eating disorder. Although sex differences have been described in both binge-eating and ghrelin signaling, this interaction has not been fully elucidated. Here, we show that ghrelin deficiency affects the behavior and metabolism of mice in a binge-like eating paradigm, and that the sex of the mice impacts the magnitude and direction of these effects.
Topics & Concepts
GhrelinBinge eatingEndocrinologyInternal medicineAppetiteAdipose tissueThermogenesisObesityMedicineHormoneRegulation of Appetite and ObesityBiochemical Analysis and Sensing TechniquesAdipose Tissue and Metabolism