Direct Synthesis of Fused Thienoindoles via Base Promoted Double C−H Sulfuration with Elemental Sulfur
Shanping Chen, Kai Hu, Wei Feng, Guojiang Mao, Yuxia Li, Guo‐Jun Deng
Abstract
Abstract A direct strategy for the preparation of fused thienoindoles from substituted indoles and elemental sulfur has been reported. The present approach produces a range of structurally valuable fused thienoindoles in 51–78% yield under transition‐metal‐free conditions, which may have potential applications in pharmaceutical industry and organic functional materials. In this work, the double C−S bonds formation is achieved via base promoted direct sulfuration of C−H bonds with elemental sulfur.
Topics & Concepts
ChemistrySulfurYield (engineering)Elemental analysisBase (topology)Transition metalCombinatorial chemistryDouble bondOrganic chemistryCatalysisMetallurgyMaterials scienceMathematical analysisMathematicsSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsSynthesis of heterocyclic compounds