Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice
Claudio Villalobos, Michele A. Basso
Abstract
spiking in SC output neurons and also reduce the likelihood of contralateral orienting in vivo. On the basis of these results, we propose that, in addition to the permissive role, the BG may play an active role in the generation of orienting movements in mice by driving post-inhibitory rebound depolarization in SC output neurons.
Topics & Concepts
OptogeneticsNeuroscienceSuperior colliculusInhibitory postsynaptic potentialDepolarizationStimulationGABAergicSubstantia nigraPremovement neuronal activityBasal gangliaChemistryBiologyDopamineCentral nervous systemBiophysicsDopaminergicNeuroscience and Neuropharmacology ResearchNeuroscience and Neural EngineeringPhotoreceptor and optogenetics research