Rhodium complexes with planar-chiral cyclopentadienyl ligands: synthesis from <i>tert</i>-butylacetylene and catalytic performance in C–H activation of arylhydroxamates
Andrey V. Kolos, Yulia V. Nelyubina, Evgeniya Podyacheva, Dmitry S. Perekalin
Abstract
. The enantiomers of these planar-chiral complexes were separated by thin-layer chromatography in the presence of L-phenylglycinol. The complexes catalyze the reactions of arylhydroxamates with alkenes giving dihydroisoquinolones in excellent yields (80-90%), but with moderate enantioselectivity (typically 20-50% ee).
Topics & Concepts
RhodiumCyclopentadienyl complexCatalysisChemistryPlanarPlanar chiralityStereochemistryMedicinal chemistryCombinatorial chemistryEnantioselective synthesisOrganic chemistryComputer graphics (images)Computer scienceCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms