Computational optimization of antibody humanness and stability by systematic energy-based ranking
Ariel Tennenhouse, Lev Khmelnitsky, Razi Khalaila, Noa Yeshaya, Ashish Noronha, Moshit Lindzen, Emily K. Makowski, Ira Zaretsky, Yael Fridmann Sirkis, Yael Galon-Wolfenson, Peter M. Tessier, Jakub Abramson, Yosef Yarden, Deborah Fass, Sarel J. Fleishman
Topics & Concepts
Complementarity determining regionComputational biologyAntibodyStability (learning theory)Computer scienceHomology modelingComplementarity (molecular biology)Humanized antibodyHomology (biology)BiologyGeneticsMachine learningMonoclonal antibodyGeneEnzymeBiochemistryMonoclonal and Polyclonal Antibodies ResearchTransgenic Plants and ApplicationsViral Infectious Diseases and Gene Expression in Insects