Unraveling the evolution and global transmission of high level tigecycline resistance gene tet(X)
Chaoqun Yao, Longyang Jin, Qi Wang, Meng Wang, Ruobing Wang, Meng Cai, Kaiwen Song, Hui Wang
Abstract
, floR, sul2, tet(M) and tet(Q). Temporal changes of transfer networks of tet(X) variants, IS elements and plasmids revealed that IS elements especially ISVsa3 facilitated the expansion of tet(X). Our findings highlight the substantial transmission risk of Type-C tet(X) variants. Persistent surveillance of the global transmission and evolutionary trend of tet(X) is essential.
Topics & Concepts
TigecyclineGeneBiologyResistance (ecology)Transmission (telecommunications)GeneticsEcologyComputer scienceAntibioticsTelecommunicationsPharmaceutical and Antibiotic Environmental ImpactsBacteriophages and microbial interactionsPolyamine Metabolism and Applications