Flow Chemistry under Extreme Conditions: Synthesis of Macrocycles with Musklike Olfactoric Properties
Alexandra Seemann, Johannes Panten, Andreas Kirschning
Abstract
Starting from small cyclic ketones, continuous flow synthesis is used to produce medium-sized rings and macrocycles that are relevant for the fragrance industry. Triperoxides are important intermediates in this process and are pyrolyzed at temperatures above 250 °C. The synthesis is carried out in two continuously operated flow reactors connected by a membrane-operated separator. The practicality of flow chemistry is impressively demonstrated in this work by the use of hazardous reagent mixtures (30% H2O2, 65% HNO3) and the pyrolysis of no less problematic peroxides. All new macrocycles were tested for their olfactory properties in relation to musk.
Topics & Concepts
ChemistryFlow chemistryReagentPyrolysisSeparator (oil production)Continuous flowHazardous wasteOrganic chemistryCombinatorial chemistryChemical engineeringBiochemical engineeringCatalysisThermodynamicsPhysicsEcologyEngineeringBiologyInnovative Microfluidic and Catalytic Techniques InnovationOxidative Organic Chemistry ReactionsAnalytical Chemistry and Chromatography