Asthma: role of the angiotensin‐(1‐7)/Mas (MAS1) pathway in pathophysiology and therapy
Juliana Fabiana Gregório, Maria da Glória Rodrigues‐Machado, Robson A.S. Santos, Igor Antônio Carvalho‐Ribeiro, Olivia Mendonça Nunes, Isabel Fusaro Aguiar Oliveira, Ana Victoria de Oliveira Vasconcellos, Maria José Campagnole‐Santos, Giselle Santos Magalhães
Abstract
The incidence of asthma is a global health problem and requires studies aimed for the development of new treatments to improve its clinical management, reducing personal and economic burdens on the health system. Therefore, the discovery of mediators that promote anti-inflammatory and pro-resolutive effects are highly desirable to improve lung function and quality of life of asthmatic patients. In that regard, experimental studies have shown that the angiotensin-(1-7)/Mas receptor (MAS1) of the renin-angiotensin system is a potential candidate for the treatment of asthma. Therefore, we have reviewed findings related to the function of the angiotensin-(1-7)/Mas pathway in regulating the processes associated with inflammation, including leukocyte influx, fibrogenesis, pulmonary dysfunction and the resolution of inflammation in asthma. Thus, a knowledge of the role of the angiotensin-(1-7)/Mas can help pave the way for the development of new treatments for this disease, which has high morbidity and mortality, through new types of experiments and clinical trials.