Fabrication and Evaluation of Transdermal Microneedles for a Recombinant Human Keratinocyte Growth Factor
Melbha Starlin Chellathurai, Vivien WangTing LING, Palanirajan Vijayaraj Kumar
Abstract
OBJECTIVES: techniques. MATERIALS AND METHODS: drug release and to perform a microneedle insertion test. Enzyme-linked immunosorbent assay was used to quantify rHuKGF. RESULTS: within 30 minutes. The strength of the microneedles in the patch was good, as they were able to reach a depth of 381±3.56 µm into parafilm without any structural change or fracture. CONCLUSION: Microneedle transdermal patches were successfully prepared for rHuKGF, and their evaluation suggested excellent quality and uniformity of patch characteristics. This can have potential applications in the therapeutic arena, offering advantages in terms of reduced dosing frequency, improved patient compliance, and bioavailability.