Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19
James F. Demarest, Maryline Kienle, RuthMabel Boytz, Mary Ayres, Eun‐Jung Kim, J. J. Patten, Donghoon Chung, Varsha Gandhi, Robert A. Davey, David B. Sykes, Nadim Shohdy, John C. Pottage, Vikram Sheel Kumar
Topics & Concepts
Dihydroorotate dehydrogenaseViral replicationPyrimidine metabolismCoronaviridaeVirologyCoronavirusBiologyIntracellularAntiviral drugViral life cycleIn vitroVirusPurinePyrimidineEnzymeMedicineBiochemistryCoronavirus disease 2019 (COVID-19)PathologyDiseaseInfectious disease (medical specialty)Biochemical and Molecular ResearchRNA modifications and cancerHIV/AIDS drug development and treatment