Differential role of melatonin in healthy brain aging: a systematic review and meta-analysis of the SAMP8 model
Dewan Md. Sumsuzzman, Zeeshan Ahmad Khan, Jeong‐Hyun Choi, Yonggeun Hong
Abstract
< 0.00001). No differences were found in catalase and superoxide dismutase activities between MT-treated and vehicle-treated groups. Furthermore, nuclear-factor-κB, cyclin-dependent kinase-5, and p53 were regulated by MT administration. MT may improve physiological stability during aging by regulating interactions in brain senescence, but acts differentially on the antioxidant system.
Topics & Concepts
MelatoninMeta-analysisNeurosciencePsychologyDifferential (mechanical device)Brain agingSystematic reviewCognitive psychologyCognitive scienceMedicineMEDLINEInternal medicineBiologyCognitionPhysicsBiochemistryThermodynamicsCircadian rhythm and melatoninSpaceflight effects on biologyGenetics, Aging, and Longevity in Model Organisms