Time‐Economical Synthesis of Bis‐Spiro Cyclopropanes via Cascade 1,6‐Conjugate Addition/Dearomatization Reaction of <i>para</i>‐Quinone Methides with 3‐Chlorooxindoles

Abstract

A spirocyclopropanation of para ‐quinone methides with 3‐chlorooxindoles that proceeds via cascade 1,6‐conjugate addition/dearomatization reaction has been established, leading to a novel class of bis‐spiro compounds in a concise, rapid, and practical manner. This transformation could be completed in high yields at room temperature within 5 min. The resulting bis‐spiro cyclopropane derivatives are of great interest because of their potential biological activity and further reaction potential.

Topics & Concepts