Ru(<scp>iii</scp>) complexes with pyrazolopyrimidines as anticancer agents: bioactivities and the underlying mechanisms
Yun‐Qiong Gu, Wen‐Ying Shen, Qi‐Yuan Yang, Zhen‐Feng Chen, Hong Liang
Abstract
Ruthenium(III) complex with pyrazolopyrimidine inhibited tumor cells proliferation, caused DNA damage by interacting with DNA and inhibition of the Topo I enzyme, induced cell cycle arrest in S phase and apoptosis via mitochondrial dysfunction.
Topics & Concepts
CytotoxicityApoptosisChemistryDownregulation and upregulationCell cycleCytochrome cReactive oxygen speciesCyclin-dependent kinaseIntracellularCell biologyCell cycle checkpointCancer cellProgrammed cell deathMolecular biologyBiochemistryBiologyIn vitroCancerGeneticsGeneMetal complexes synthesis and propertiesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds