SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction
Stefanie Deinhardt‐Emmer, Sarah Böttcher, C. M. Haring, Liane N. Giebeler, Andreas Henke, Roland Zell, Johannes Jungwirth, Paul M. Jordan, Oliver Werz, Franziska Hornung, Christian Brandt, Mike Marquet, Alexander S. Mosig, Mathias W. Pletz, Michael Schacke, Jürgen Rödel, Regine Heller, Sándor Nietzsche, Bettina Löffler, Christina Ehrhardt
Abstract
experiments, but we were able to show the destruction of the epithelial-endothelial barrier in our chip model. From our experiments we can assume that virus-induced host factors disturbed the epithelial-endothelial barrier function and thereby promote viral spread.
Topics & Concepts
BiologyViral replicationBarrier functionInterferonViral entryInflammationVirologyEpitheliumViral sheddingVirusImmunologyImmune systemCoronavirusPeripheral blood mononuclear cellEndothelial stem cellDiseaseCell biologyCoronavirus disease 2019 (COVID-19)PathologyIn vitroMedicineInfectious disease (medical specialty)BiochemistryGeneticsCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19