RNA-targeting low-molecular-weight fluorophores for nucleoli staining: synthesis, <i>in silico</i> modelling and cellular imaging
Atanas Kurutos, Jasmina Nikodinović‐Runić, Aleksandar M. Veselinović, Jovana B. Veselinović, Fadhil S. Kamounah, Tatjana Ilic‐Tomic
Abstract
Herein we present our work on the synthesis, investigation of the photophysical properties, interactions with nucleic acids, molecular docking, and imaging application of three carbocyanine dyes.
Topics & Concepts
ChemistryNucleolusIn silicoRNAStainingComputational biologyBiophysicsMolecular biologyCell biologyBiochemistryPathologyGeneCytoplasmMedicineBiologyRNA and protein synthesis mechanismsDNA and Nucleic Acid ChemistryRNA modifications and cancer