Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)
Guy Kleks, Darren C. Holland, Joshua Porter, Anthony R. Carroll
Abstract
. These new methodologies allow the MW of compounds in mixtures to be predicted without the need for MS analysis, the dereplication of known compounds and identification of new compounds based solely on parameters derived by DOSY NMR.
Topics & Concepts
ChemistryDiffusionNuclear magnetic resonance spectroscopyMass spectrometryComputational chemistryAnalytical Chemistry (journal)Organic chemistryChromatographyThermodynamicsPhysicsNMR spectroscopy and applicationsMetabolomics and Mass Spectrometry StudiesMolecular spectroscopy and chirality