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In vitro and in vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC)

Yubo Wang, Yuanyuan Zhou, Sheng Cao, Yue Sun, Zhiqiang Dong, Chen Li, Haoran Wang, Yuhong Yao, Haiyan Yu, Xiangyi Song, Ming Li, Jiefu Wang, Mingming Wei, Guang Yang, Cheng Yang

2021Bioorganic Chemistry86 citationsDOI

Topics & Concepts

In vivoChemistryImmunotherapyProteolysisCancer immunotherapyProteasomeProtein degradationPD-L1Programmed cell deathIn vitroCell biologyImmune systemCancer researchAntibodyBiochemistryImmunologyApoptosisBiologyBiotechnologyEnzymeCAR-T cell therapy researchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis
In vitro and in vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC) | Litcius