Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration
Geneva LaForce, Jordan S. Farr, Jingyi Liu, Cydni Akesson, Evren Gümüş, Otis Pinkard, Helen C. Miranda, Katherine Johnson, Thomas J. Sweet, Ping Ji, Lin Ai, Jeff Coller, Polyxeni Philippidou, Eric J. Wagner, Ashleigh E. Schaffer
Topics & Concepts
Gene isoformPolyadenylationBiologyCleavage and polyadenylation specificity factorNeurodegenerationMessenger RNACleavage factorCell biologyAlternative splicingRNARNA polymerase IIGene expressionCleavage stimulation factorMolecular biologyTranscription (linguistics)GeneGeneticsDiseasePathologyPromoterLinguisticsPhilosophyMedicineRNA Research and SplicingRNA modifications and cancerNeurogenetic and Muscular Disorders Research