Engineering carbonyl reductase for one-pot chemobiocatalytic enantioselective synthesis of a value-added N-containing chiral alcohol from <i>N</i>-acetyl-<scp>d</scp>-glucosamine
Yacheng Hao, Min‐Hua Zong, Qi Chen, Ning Li
Abstract
Engineering of carbonyl reductase was performed to improve both activity and stability, thus allowing for chemobiocatalytic conversion of cheap NAG into a N-containing chiral alcohol by merging it with chemical catalysts.
Topics & Concepts
Enantioselective synthesisAlcoholChemistryCatalysisReductaseBiocatalysisOrganic chemistryCombinatorial chemistryEnzymeStereochemistryReaction mechanismEnzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and BioproductionCatalysis for Biomass Conversion