Design, synthesis, and antibacterial activity of <i>N</i> -(trifluoromethyl)phenyl substituted pyrazole derivatives
Ibrahim A. Saleh, Hansa Raj KC, Subrata Roy, Mohd Kotaiba Abugazleh, Hashim Ali, David F. Gilmore, Mohammad A. Alam
Abstract
. Investigations into the mode of action by performing macromolecular synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function.
Topics & Concepts
Enterococcus faecalisAntimicrobialEnterococcus faeciumPyrazoleMicrobiologyStaphylococcus aureusPotencyChemistryAntibioticsTrifluoromethylBacteriaVancomycinCombinatorial chemistryIn vitroBiologyStereochemistryBiochemistryOrganic chemistryAlkylGeneticsClick Chemistry and ApplicationsAntifungal resistance and susceptibilityAntimicrobial Resistance in Staphylococcus