Circular RNA circ_ASAP2 promotes cell viability, migration, and invasion of gastric cancer cells by regulating the miR-770-5p/CDK6 axis.
Bing Chen, Fei Ji, Xinian Wen, Zhong Jin
Abstract
BACKGROUND: Gastric cancer (GC) is one of the most common causes of cancer death. GSE83521 microarray analysis suggested that circular RNA circ_ASAP2 (hsa_circ_0008768) expression was increased in GC tissues. However, the molecular mechanism of circ_ASAP2 remains unknown. METHODS: . RESULTS: . CONCLUSION: Circ_ASAP2 knockdown can repress the development of GC cells partly through regulating the miR-770-5p/CDK6 axis, suggesting an underlying circRNA-targeted therapy for GC treatment.
Topics & Concepts
Cyclin-dependent kinase 6Gene knockdownViability assayChemistryCell growthmicroRNAGene silencingCancer researchMolecular biologyCircular RNABiologyCellApoptosisCyclin D1Cell cycleBiochemistryGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research