Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
S. Siméon, Laurent Dortet, Frédérique Bouchand, Anne‐Laure Roux, Rémy A. Bonnin, Clara Duran, Jean‐Winoc Decousser, Simon Bessis, Benjamin Davido, G. Sorriaux, Aurélien Dinh
Abstract
We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome.
Topics & Concepts
ColistinAntibioticsEnterobacterDrug resistanceOverproductionDrugAntibiotic resistanceBiologyMedicineMicrobiologyPharmacologyGeneGeneticsEscherichia coliAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and Resistance