Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling
Li Li, Bing Wang, Yawei Li, Lei Li, Yuliang Dai, Guohua Lv, Pengfei Wu, Pengzhi Li
Abstract
. Mechanistically, Celastrol was able to control the differentiation of BM-MSCs by stimulating PGC-1α signaling. Moreover, administration of Celastrol could alleviate bone loss and bone marrow adipose tissue (MAT) accumulation in ovariectomized (OVX) mice and aged mice. Together, these results recommended that Celastrol could regulate BM-MSCs fate and bone-fat balance in OP and skeletal aging by stimulating PGC-1α, which might act as a possible therapeutic target for OP and for the prevention of skeletal aging.
Topics & Concepts
CelastrolMesenchymal stem cellOsteoblastBone marrowOsteoporosisAdipose tissueEndocrinologyInternal medicineMedicineStem cellBone healingOvariectomized ratCancer researchChemistryCell biologyBiologyPathologyIn vitroAnatomyEstrogenBiochemistryApoptosisNatural Compounds in Disease TreatmentBone Metabolism and DiseasesRetinoids in leukemia and cellular processes