The cohesin stabilizer Sororin drives G <sub>2</sub> -M transition and spindle assembly in mammalian oocytes
Changyin Zhou, Xue Zhang, Yilong Miao, Yu Zhang, Yu Li, Bo Xiong
Abstract
, which drives M phase entry and bipolar spindle formation. Notably, the meiotic functions of Sororin are conserved among mammals. Together, our findings provide novel insights into the noncanonical role of Sororin in the resumption of meiosis and progression through meiosis I in mammalian oocytes.
Topics & Concepts
CohesinCell biologyStabilizer (aeronautics)ChemistryBiologyBiophysicsMeiosisBiochemistryEngineeringMechanical engineeringGeneMicrotubule and mitosis dynamicsReproductive Biology and FertilityPhotosynthetic Processes and Mechanisms