α-Aminoboronates: recent advances in their preparation and synthetic applications
Wenbo Ming, Harjeet S. Soor, Xiaocui Liu, Alina Trofimova, Andrei K. Yudin, Todd B. Marder
Abstract
as α-aminomethylation reagents for the synthesis of chiral nitrogen-containing molecules, as nucleophiles for preparing valuable vicinal amino alcohols, and as bis-nucleophiles in the construction of valuable small molecule scaffolds. This review summarizes new methodology for the preparation of α-aminoboronates, including highlights of asymmetric synthetic methods and mechanistic explanations of reactivity. Applications of α-aminoboronates as versatile synthetic building blocks are also discussed.
Topics & Concepts
NucleophileCombinatorial chemistryChemistryVicinalReagentOrganic synthesisFood and drug administrationNanotechnologyOrganic chemistryMaterials sciencePharmacologyCatalysisMedicineOrganoboron and organosilicon chemistryChemical Synthesis and AnalysisSulfur-Based Synthesis Techniques