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Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis

Yonghong Liang, Sixin Chen, Suqin Han, Li Luo, Feihai Shen, Zhiying Huang

2023Toxicology Letters20 citationsDOI

Topics & Concepts

ATF4GPX4GlutathioneReactive oxygen speciesChemistryKinaseOxidative stressCell biologySignal transductionTranscription factorUnfolded protein responseMolecular biologyBiochemistryApoptosisBiologyGlutathione peroxidaseSuperoxide dismutaseEnzymeGeneFerroptosis and cancer prognosisGenomics, phytochemicals, and oxidative stressCancer Mechanisms and Therapy
Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis | Litcius