Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance
Lige Leng, Ziqi Yuan, Rui‐Yuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Hui Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi‐Bing Jin, Sheng‐Xi Wu, Xinglong Wang, Zengqiang Yuan, Huaxi Xu, Hei‐Man Chow, Jie Zhang
Topics & Concepts
MicrogliaDownregulation and upregulationPhagocytosisAdenosine triphosphateLipid metabolismHexokinaseBiologyTREM2GlycolysisNeurodegenerationCell biologyAmyloid (mycology)MetabolismChemistryBiochemistryInternal medicineInflammationImmunologyMedicineDiseaseBotanyGeneNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsAdenosine and Purinergic Signaling