Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping
Sua Bae, Keyu Liu, Antonios N. Pouliopoulos, Robin Ji, Sergio Jiménez-Gambín, Omid Yousefian, Alina R. Kline-Schoder, Alec J. Batts, Fotios N. Tsitsos, Danae Kokossis, Akiva Mintz, Lawrence S. Honig, Elisa E. Konofagou
Abstract
: We showed the safety and feasibility of this cost-effective and time-efficient portable NgFUS treatment for BBBO in AD patients with the first demonstration of real-time 2-D cavitation mapping. The cavitation dose correlated with BBBO volume, a slowed increase in pathology, and serum detection of AD proteins. Our study highlights the potential for accessible FUS treatment in AD, with or without drug delivery.
Topics & Concepts
Transcranial DopplerFocused ultrasoundBlood–brain barrierUltrasoundCavitationMedicineBiomedical engineeringPathologyNeuroscienceInternal medicineCentral nervous systemRadiologyPsychologyAcousticsPhysicsUltrasound and Hyperthermia ApplicationsTraumatic Brain Injury and Neurovascular Disturbances