RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges
Lele Ye, Xuyang Yao, Binbing Xu, Wenwen Chen, Han Lou, Xinya Tong, Fang Su, Ruanmin Zou, Yingying Hu, Zhibin Wang, Dan Xiang, Qiaoai Lin, Shiyu Feng, Xiangyang Xue, Gangqiang Guo
Abstract
Abstract Ovarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m 6 A, m 1 A, and m 5 C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m 6 A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment. This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease