Transformative Approaches in Bone Pathology Treatment: The Efficacy of Alendronate-Infused Hydroxyapatite Microspheres
Sarad Pawar Naik Bukke, Saswati Mishra, Chandrashekar Thalluri, Cheedipudi Srinivas Reddy, Ananda Kumar Chettupalli, Gali Avinash Kumar
Abstract
Alendronate (ALD), when administered orally, has several limitations, including poor bioavailability and gastrointestinal irritation. This study addresses the need for a sustained local delivery system for ALD by fabricating Hydroxyapatite (HA) hollow microspheres using a simple template-directed method with mustard seeds as the template. ALD was adsorbed onto the surface of the HA hollow microspheres at varying concentrations (0.05 µM to 0.2 µM). The microsphere characteristics properties of th
Topics & Concepts
MicrosphereTransformative learningMedicineDentistryPathologyPsychologyChemical engineeringEngineeringPedagogyBone Tissue Engineering MaterialsBone health and treatmentsChemical Synthesis and Characterization