Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy
Song Lin, Houjin Jing, Xiao‐Jiao Du, Xianzhu Yang, Jun Wang
Abstract
-PLGA, a cationic lipid, and an ionizable lipid. We optimized this system by carefully adjusting their mass ratios, resulting in highly efficient gene silencing. Furthermore, the optimized nanoparticle formulation, which encapsulates siRNA targeting CD47, induces a robust immune response. This response effectively suppresses the progression of melanoma tumors by blocking this critical immune checkpoint.
Topics & Concepts
PLGAImmunotherapyCancer immunotherapyCationic polymerizationChemistryCancerNanoparticleDelivery systemCancer researchNanotechnologyBiophysicsBiomedical engineeringMaterials scienceMedicineBiologyPolymer chemistryInternal medicineRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesImmunotherapy and Immune Responses