Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O’Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
Abstract
Mouse models leading to accelerated fatty liver onset are a useful translational tool. Here we show that coupling thermoneutral-like housing and Western diet feeding in mice for 16 wk does not lead to significant disease progression in either sex, though the molecular phenotype indicates priming of immune-related and fibrotic pathways.
Topics & Concepts
SteatosisFatty liverInternal medicineEndocrinologyInflammationFibrosisLiver injuryPathogenesisBiologyTriglycerideDiseaseMedicineCholesterolLiver Disease Diagnosis and TreatmentAdipose Tissue and MetabolismDiet and metabolism studies