Corneal ulceration associated with dupilumab use in a patient with atopic dermatitis
Gavin Li, Meghan Berkenstock, Uri Soiberman
Abstract
PURPOSE: To describe a case of corneal ulceration associated with dupilumab use for atopic dermatitis. OBSERVATIONS: A patient developed an inflammatory corneal ulcer 3 weeks after starting bi-weekly intravenous dupilumab therapy. Symptoms resolved with topical prednisolone and discontinuation of the systemic therapy with dupilumab. CONCLUSION AND IMPORTANCE: Dupilumab is known to cause ocular surface inflammation, but we report a novel association between dupilumab use and potentially sight-threatening corneal ulceration.
Topics & Concepts
DupilumabMedicineAtopic dermatitisDermatologyDiscontinuationPrednisoloneSurgeryDermatology and Skin DiseasesUrticaria and Related ConditionsContact Dermatitis and Allergies