Formulation and evaluation of inhaled Sildenafil-loaded PLGA microparticles for treatment of pulmonary arterial hypertension (PAH): A novel high drug loaded formulation and scalable process via hot melt extrusion technology (Part Ⅰ)
Mashan Almutairi, Amr Hefnawy, Ahmed Almotairy, Ahmed Alobaida, Mohammed Alyahya, Abdulmajeed Althobaiti, Ahmed Adel Ali Youssef, Rasha M. Elkanayati, Eman A. Ashour, Hugh D. C. Smyth, Michael A. Repka
Topics & Concepts
PLGAParticle sizeMaterials scienceBiomedical engineeringExtrusionGeometric standard deviationDrug deliverySildenafilChemistryComposite materialNanotechnologyNanoparticleMedicineAerosolOrganic chemistryInternal medicinePhysical chemistryInhalation and Respiratory Drug DeliveryPulmonary Hypertension Research and Treatments