FOXO1 deficiency impairs proteostasis in aged T cells
Jun Jin, Xuanying Li, Bin Hu, Chulwoo Kim, Wenqiang Cao, Huimin Zhang, Cornelia M. Weyand, Jörg J. Goronzy
Abstract
T cells develop features reminiscent of senescent cells. They acquire an increased cell mass, preferentially differentiate into short-lived effector T cells, and secrete exosomes that harm cells in the local environment through the release of granzyme B.
Topics & Concepts
ProteostasisFOXO1Cell biologyCellBiologyMedicineSignal transductionGeneticsProtein kinase BFOXO transcription factor regulationGenetics, Aging, and Longevity in Model Organisms