PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma
Tianyi Jiang, Yufei Pan, Zhenghua Wan, Yun‐Kai Lin, Bin Zhu, Zhen-Gang Yuan, Yunhan Ma, Yuanyuan Shi, Tian-Mei Zeng, Liwei Dong, Yexiong Tan, Hongyang Wang
Abstract
BACH1 and MAFF are transcriptional regulators that recognize the antioxidant response element, which is present in genes encoding proteasome subunits. PTEN induced the accumulation and nuclear translocation of these proteins, which directly repressed the transcription of genes encoding proteasome subunits. We revealed that the PTEN-proteasome axis is a potential target for therapy in PTEN-deficient CCA and other PTEN-deficient cancers.
Topics & Concepts
PTENCancer researchChemosensitivity assayProteasomeInternal medicineMedicineChemistryOncologyApoptosisPI3K/AKT/mTOR pathwayBiochemistryTumor cellsCholangiocarcinoma and Gallbladder Cancer StudiesRNA modifications and cancerPeptidase Inhibition and Analysis