Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages
Mohamed M. S. Hamoud, Nermine A. Osman, Samar Rezq, Hend A. A. Abd El-wahab, Abdalla E. A. Hassan, Hanan A. Abdel‐Fattah, Damián G. Romero, Amany M. Ghanim
Topics & Concepts
ChemistryCelecoxibIC50PharmacologyOxadiazoleAntioxidantDiclofenac SodiumCyclooxygenaseAnti-inflammatoryNitric oxideReactive oxygen speciesArachidonate 5-lipoxygenaseIn vitroBiochemistryEnzymeArachidonic acidOrganic chemistryChromatographyMedicineSynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects