Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking
Lauren K. Park, Elizabeth J. Parks, Ryan Pettit‐Mee, Makenzie L. Woodford, Thaysa Ghiarone, James Smith, Allan R. K. Sales, Luis A. Martinez‐Lemus, Camila Manrique‐Acevedo, Jaume Padilla
Abstract
This report provides evidence that in sedentary subjects with type 2 diabetes diminished insulin-stimulated increases in leg vascular conductance and ensuing blunted capillary perfusion in skeletal muscle are not restorable by increased walking alone. More innovative physical activity interventions that ultimately result in a robust mitigation of metabolic risk factors may be vital for reestablishing skeletal muscle microvascular insulin sensitivity in type 2 diabetes.
Topics & Concepts
Insulin resistanceSkeletal muscleType 2 diabetesInternal medicineMedicineEndocrinologyInsulinDiabetes mellitusCardiologyAnatomyCardiovascular and exercise physiologyCardiovascular Function and Risk FactorsNutrition and Health in Aging