The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain
Radmila Micanovic, Kaice A. LaFavers, Kavish R. Patidar, Marwan Ghabril, Emma H. Doud, Amber L. Mosley, Angela R. Sabo, Shehnaz Khan, Tarek M. El‐Achkar
Abstract
In this work, we discovered and characterized a novel form of uromodulin that does not polymerize because it retains an external hydrophobic patch at the COOH-terminus. These findings establish an alternative form of cellular processing of this protein and elucidate new aspects of its biology. We also provide evidence suggesting that measuring urinary nonpolymerizing uromodulin could be a promising assay to assess the risk of acute kidney injury.
Topics & Concepts
Tamm–Horsfall proteinKidneyUrinary systemUrineChemistryCell biologyBiologyBiochemistryAnatomyEndocrinologyKidney Stones and Urolithiasis TreatmentsChronic Kidney Disease and DiabetesAcute Kidney Injury Research