ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance
Xixi Zeng, Maoping Wan, Jianmin Wu
Abstract
Fig. 1 Schematic summary of roles of amplified ecDNAs in cancer. EcDNA-based oncogene amplification promotes intratumoral genetic heterogeneity and is associated with aggressive cancer behavior, including tumor growth, metastasis, and drug resistance, resulting in poor outcomes for patients across multiple cancers ecDNA within tumors: a new mechanism that drives tumor heterogeneity and. . .
Topics & Concepts
Mechanism (biology)MetastasisDrug resistanceOncogeneTumor heterogeneityGenetic heterogeneityCancer researchCancerDrugBiologyMedicineGeneticsPharmacologyPhenotypeGeneCell cycleEpistemologyPhilosophyCancer Genomics and DiagnosticsCRISPR and Genetic EngineeringRNA modifications and cancer