Comparing the Population Pharmacokinetics of and Acute Kidney Injury Due to Polymyxin B in Chinese Patients with or without Renal Insufficiency
Peile Wang, Qiwen Zhang, Zhenfeng Zhu, Hui Pei, Min Feng, Tongwen Sun, Jing Yang, Xiaojian Zhang
Abstract
Despite excellent bactericidal effect, dosing adjustment of polymyxin B for patients with renal insufficiency and polymyxin B-related nephrotoxicity is still a major concern to clinicians. The aim of this study was to compare the population pharmacokinetics (PK) properties of polymyxin B in Chinese patients with different renal functions and to investigate the relationship between PK parameters and polymyxin B-related acute kidney injury (AKI). A total of 37 patients with normal renal function (creatinine clearance ≥ 80 ml/min) and 33 with renal insufficiency (creatinine clearance < 80 ml/min) were included.
Topics & Concepts
NephrotoxicityRenal functionPolymyxin BMedicineAcute kidney injuryPharmacokineticsPolymyxinCreatininePopulationDosingUrologyKidneyAntibioticsInternal medicinePharmacologyIntensive care medicineBiologyMicrobiologyEnvironmental healthAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatment