Radical Acylfluoroalkylation of 1,3-Enynes via <i>N</i>-Heterocyclic Carbene/Photoredox Cooperative Catalysis
Shichao Tian, Ning Chen, Keguang Cheng, Quande Wang
Abstract
-heterocyclic carbene (NHC)/photoredox catalysis toward various fluorinated allenic aryl ketones. This protocol features a broad substrate scope and excellent functional group tolerability, with examples of late-stage modification of drug molecules and natural products. Notably, seven different fluoroalkyl motifs can be introduced to 1,3-enynes, further demonstrating the robustness and generality of this method. The generation of the fluoroalkyl radical from each sulfinate reagent was individually supported by EPR experiments.
Topics & Concepts
CarbeneChemistryCatalysisPhotoredox catalysisMedicinal chemistryCombinatorial chemistryPhotochemistryOrganic chemistryPhotocatalysisFluorine in Organic ChemistryRadical Photochemical Reactions