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Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism

Lai Wang, Lijun Zhu, Zu‐Guo Zheng, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang

2022Metabolism10 citationsDOI

Topics & Concepts

GeranylgeranylationGeranylgeranyl pyrophosphateGeranylgeraniolProtein kinase BSimvastatinCarbohydrate metabolismInsulinInsulin receptorBiologyPI3K/AKT/mTOR pathwayEndocrinologyInternal medicineSignal transductionPrenylationCell biologyBiochemistryInsulin resistanceMedicineFarnesolEnzymeEndoplasmic Reticulum Stress and DiseaseProtein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathways
Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism | Litcius